Mineralized Tissue Biology and Diseases

ORB 614 Subject & Catalog Number

Description

The focus of this course is on the biology and pathology of mineralized tissues, including bone, cartilage and the tooth components. In the first part, the extracellular matrix, its inorganic, organic, and cellular components and the mechanisms by which the extracellular matrix is formed and remodeled will be analyzed. These basic principles will then be applied to tissues such as teeth, bone, and cartilage and will explain common features as well as tissue-specific aspects, integrating the biology and the pathology of the most significant diseases. The course will cover diseases affecting these tissues such as gain- or loss of bone mass (osteoporosis and
osteopetrosis) and osteo-arthritis and Rheumatoid arhtritis, as well as a detailed description of the calcium and phosphate metabolism and its disrders. The course will then move on to local treatment-related topics including distraction osteogenesis and bone regeneration. After completion of the course, the participant will have an in-depth understanding of the skeletal and tooth system, the extracellular matrix, its components, diseases, and treatment options.