Oral Immunology

ORB 602 Subject & Catalog Number

Description

An introduction to basic immunology with emphasis on aspects of immunology relevant to the oral environment followed by an in depth survey of immunological phenomena operative in the oral cavity.  The nature of innate and adaptive immunities is considered with emphasis on immune selective mechanisms, recognition, cellular interaction, development of immunity, and generation of diversity to meet the challenges of the host.  Also considered are the genetics of the adaptive immune system, tolerance, control mechanisms and the nature of chemokines, cytokines and the association with immune cell subdivisions and specialization.  Major emphasis is placed on the immune system of mucosal surfaces.  The cellular dynamics and interactions in induction of mucosal immunity including unique molecules, synthesis and structures are highlighted.  The impact of mucosal immunity on the oral cavity and the potential for basic immune mechanisms and the uniqueness of these oral environments are considered in depth.  The molecular pathogeneses of major oral infectious diseases including dental caries, periodontal diseases, and pulpal infection are considered extensively in relation to host immunity to these infections and the philosophy of vaccine formulation. In addition, the etiology and oral manifestation of autoimmune diseases such as Sjogrens Syndrome and bullous diseases are considered in depth.  There is also discussion of human immunodeficiency virus infection, emphasizing the oral cavity and effects on oral and other immune mechanisms.  Outside reading of 4 hours per week are part of this course.