Mechanisms of Bacterial Pathogenesis and Host Immune Response

MICROBI 202 Subject & Catalog Number

Description

This course focuses on molecular mechanisms of bacterial pathogenesis and the host response to infection. The class consists of lectures and group discussions emphasizing themes of pathogenesis, methods, results, and interpretations of classic and contemporary literature.

Subjects including bacterial secretion systems, mechanisms of entry into host cells, biofilm formation, and motility are viewed primarily from the pathogen’s perspective, whereas topics including inflammasome activation, TLR signaling, and adaptive immune responses provide a host-centric view. Additional sessions are spent examining current methods of antibiotic discovery, vaccine development and the microbiome.

The course also introduces students to the wide diversity of pathogenic bacteria. Organisms discussed include pathogenic E. coli, Shigella species, Vibrio cholerae, Listeria monocytogenes, Chlamydia trachomatis, Pseudomonas aeruginosa and Staphylococcus aureus, as well as a discussion of the challenges presented by currently unculturable species. Where relevant, connections will also be made with pathogenesis and immune responses to viruses, parasites, and fungi.

Course Notes

Designed to complement Microbiology 201; however, students who have not taken Microbiology 201 previously are welcome. Designed for graduate students in their first year or beyond, however undergraduates with specific interest in the field may also enroll.