Understanding the Seemingly Impossible: A Revolution in Biology
FYSEMR 51F
Subject & Catalog Number
Course Information
Description
Occasionally a scientific discovery is so unexpected that it is seemingly unexplainable. This seminar will revisit one such event, the discovery of RNA interference and how modern experimental molecular genetics cracked this problem and started a billion-dollar industry. Rare, unexpected discoveries in biology, for example catalytic RNAs, instantly extend and broaden our understanding of the world, while the impact of other discoveries (split genes, hopping genes) are more gradual.
However, some discoveries challenge firmly supported ideas. The initial description of RNA interference (RNAi) was seemingly magical the introduction of a RNA molecule matching the sequence of any gene, results in the effective silencing (turning off) of the gene. Further, the silencing signal(s) were extremely potent and mobile, moving between cells, tissues, and generations. A series of seminal discoveries during an amazing four-year period revealed the previously unimagined process.
We will read and talk about how these discoveries were made and how this unexpected new biology launched new therapeutic companies and is informing developing ideas about heritability, adaptation, and evolution.
Class Notes
First-Year Seminars are available only to first-year students. You may apply to both Fall 2026 and Spring 2027 First-Year Seminars via the FYS lottery between July 6 and August 6, 2026 at 11:59PM-midnight.
You may apply to as many seminars each term as you would like, but we recommend you apply to at least six in fall and three in spring.
As part of your application, you must provide a brief statement on why you are interested in each seminar. You will be notified of lottery results for both fall and spring seminars at 5 pm on August 11. If you are unsuccessful in the lottery, you may still join any seminar with open seats. A list of open seminars and instructions on next steps will be available on the First-Year Seminar Program website August 11 at 12 Noon.
Not Available for Cross Registration
